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Albany Medical College
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main page
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lab members
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research projects
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publications
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videos
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Albany Medical College
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Barbara L. Lewis
Research Lab Manager
Research Interests:
I am currently looking at the effects of VTA stimulation on the bistable membrane potential states of pyramidal neurons in the prefrontal cortex, and the receptors involved, using in vivo intracellular recording techniques. In addition I am looking at these effects in animals that have undergone a neonatal ventral hippocampal lesion, a proposed animal model of schizophrenia. Due to the changes we have seen in these animals. I am also doing in vivo extracellular recording in the VTA, with preliminary results indicating an increase in the firing rate of the dopamine cells. These studies are also being investigated using anatomical tracing and receptor and protein immunohistochemical localization techniques, in an effort to elucidate the mechanisms and circuitry involved.
Curriculum Vitae
Education:
University at Albany, Albany NY B.S., Biology, Teacher Education 1992
University at Albany, Albany NY M.S. Neurobiology 1995
Publications
Peer-reviewed articles:
Goto, Y, Tseng, K.Y., Lewis, B.L. and O’Donnell, P. Dopamine modulation
of prefrontal cortical neural ensembles and synaptic plasticity: Potential involvement
in schizophrenia. In: Prefrontal Cortex: from Synaptic Plasticity to Cognition.
S. Otani, Ed. Kluwer Academic Publishers, (2004) 61-84.
Lewis, B.L. and O’Donnell, P. Blockade of the GlyT1 glycine transporter
prolongs response to VTA stimulation in nucleus accumbens neurons. In: Glutamate
and Disorders of Cognition and Motivation. B. Mogghadam and M.E. Wolf, Eds. New
York Academy of Sciences, Vol 1003 (2003) 431-434
O’Donnell, P., Lewis,
B.L., Weinberger, D.R., and Lipska, B.K. Neonatal hippocampal damage alters electrophysiological
properties of prefrontal cortical neurons in adult rats. Cerebral Cortex 12 (2002)
975-982.
Lewis, B.L. and O'Donnell, P. Ventral tegmental area afferents to the prefrontal cortex maintain membrane potential 'up' states in pyramidal neurons via D1 dopamine receptors. Cerebral Cortex 10 (2000) 1168-1175.
O'Donnell, P., Greene, J., Pabello, N., Lewis, B.L. and Grace, A.A. Modulation of cell firing in the nucleus accumbens. In: Annals of the New York Academy of Science, 877 (1999) 157-175.
Abstracts and Poster papers:
Lewis, B.L., Tseng, K.Y., Amin, F. and O’Donnell, P. Increased metabolic
activity in medial prefrontal cortex following ventral tegmental area burst
stimulation in animals with a neonatal ventral hippocampal lesion. Program
No. 315.16. 2003 Abstract Viewer/Itinerary Planner. Washington, DC. Society
for Neuroscience.
Lewis, B.L. and O’Donnell, P. Prolonged depolarization of medial prefrontal
cortical neurons following activation of dopaminergic ventral tegmental area
afferents. Program No. 62.8. 2002 Abstract Viewer/Itinerary Planner. Washington,
DC: Society for Neuroscience, 2002. CD-ROM.
O’Donnell, P., Lewis, B.L. and Goto, Y. Functional alteration in mesocortical
and mesolimbic systems in animals with a neonatal hippocampal lesion. Biological
Psychiatry 51 (2002) 9S.
O’Donnell, P., Lewis, B.L., Weinberger, D.R. and Lipska, B.L. Neonatal
hippocampal damage alters physiological response properties to VTA stimulation
in the adult rat prefrontal cortex. Biological Psychiatry 51 (2002) 61S.
O’Donnell, P., Lewis, B.L. and Goto, Y. Mesolimbic dopamine systems are
altered in an animal model of schizophrenia. 7th Neurodegenerative Disorders:
Common Molecular Mechanisms, Montego Bay, Jamaica (2002) 49
Lewis, B.L., Lipska, BK, Weinberger, DR, O’Donnell, P. Neonatal hippocampal
damage alters physiological properties of the mesocortical system in adult rats.
Soc. Neurosci. Abstr. 27 (2001) 876.14
Lewis, B.L., Lipski, W.J., Weinberger, D.R., Lipska, B.K. and O'Donnell, P. A neonatal hippocampal lesion increases VTA cell firing in adult rats. Soc. Neurosci. Abstr.26 (2000) 1224.
O'Donnell, P., Lewis, B.L., Wang, J. and Peters, Y.M. Dopamine-glutamate interactions in the prefrontal cortex: changes in animal models of schizophrenia. Journal of Alzheimer's Disease 2 (2000) 161.
Peters, Y.M., Lewis, B.L. and O'Donnell, P. Synchronous activity in the ventral tegmental area and prefrontal cortex. Annals of the New York Academy of Sciences 909 (2000) 267-269.
O'Donnell, P., Lewis, B.L., Lerman, D., Weinberger, D.R. and Lipska, B.K. Effects of neonatal hippocampal lesions on prefrontal cortical pyramidal cell responses to VTA stimulation. Soc. Neurosci. Abstr. 25 (1999) 1659.
Lewis, B.L and O'Donnell, P. Stimulation of VTA induces membrane potential state transitions in prefrontal cortical neurons recorded in vivo. Soc. Neurosci. Abstr. 25 (1999) 1659.
Lewis, B.L., Peters, Y.M. and O'Donnell, P. Role of the VTA projection to the prefrontal cortex on activity states of pyramidal neurons. Gordon Research Conference in Catecholamines. Queen's College, Oxford, UK (1999).
Lewis, B. and O'Donnell, P. Effects of VTA stimulation on prefrontal cortex neurons recorded in vivo. Soc. Neurosci. Abstr. 24 (1998) 656.
O'Donnell, P. and Lewis, B. Dopaminergic control of prefrontal cortical activity: effect of VTA stimulation on bistable membrane potential of prefrontal cortical pyramidal neurons. Dopamine 98, Strasbourg, France (1998).
Awards:
Initiatives for Women Research Award
Graduate Student Organization Research Grant
Rachel B. Taubman Research Fellowship
Teaching Experience
Graduate Teaching Assistant Biology Department University at Albany
Science Educator Heldeberg Workshop, Voorheesville, NY
Professional Memberships
Society for Neuroscience
Women in Neuroscience
Hudson Berkshire Chapter of Society for Neuroscience