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Electrophysiological studies of dopaminergic actions in the prefrontal cortex in vivo

Pyramidal neurons in the prefrontal cortex (PFC) exhibit an oscillation of near 1 Hz in their membrane potential. This can also be characterized as the neurons alternating between a negative (down) and depolarized (up, or active) state. We are studying the role of the mesolimbic system in controling transitions between states as well as the state-dependency of the responses to activation of these afferents.

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