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Kuei-Yuan Tseng, M.D., Ph.D.
Postdoctoral Fellow

CURRICULUM VITAE

First Name: KUEI-YUAN

Last Name: TSENG

Date and Place of Birth: December 9, 1972 in Taiwan, China

Citizenship: ARGENTINE

Address:

Center for Neuropharmacology & Neuroscience
Albany Medical College (MC-136)
47 New Scotland Ave.
Albany, NY 12208
e-mail: tsengky@mail.amc.edu

Education:

MD: School of Medicine, University of Buenos Aires, Buenos Aires, Argentina (March 1991 - June 1997)

PhD: Department of Physiology (neuroscience), University of Buenos Aires, Buenos Aires, Argentina (1998-2001)

Academic Appointments:

Staff/Teaching assistant in Neuroscience, School of Medicine, Albany Medical College, Albany NY (2001-present)

Instructor/Lecturer, Department of Physiology & Biophysic, School of Medicine, University of Buenos Aires (1998-2001)

Instructor/Lecturer in Neurophysiology "Curso Superior de Neurología", Department of Neurology, School of Medicine, University of Buenos Aires (1997-2001)

Instructor/Lecturer in Neurophysiology "Curso Superior de Neurocirugía", Department of Neurosurgery, School of Medicine, University of Buenos Aires (1999-2001)

Teaching assistant, Department of Physiology & Biophysics, School of Medicine, University of Buenos Aires (1993-1997)
Honors and Awards:

Poster Award, VII International Triennial Meeting of International Basal Ganglia Society (IBAGS VII), Waitangi, Bay of Islands, New Zealand, February 11-15, 2001.

Member of the Board ("Consejo Departamental"), March 2000 - May 2001, School of Medicine, University of Buenos Aires elected in representation of the Department of Physiology & Biophysics Teaching assistants.

Fundación Antorchas Grant, Buenos Aires, Argentina (1999-2000). Project: El microcircuito de los Ganglios Basales: Fisiología y alteraciones en un modelo experimental de Parkinson.

Travel Award, Association Claude Bernard-INSERM U289, Hôpital de la Salpetrière, Paris, France 1999:
1. 29th Annual Meeting of the Society for Neuroscience, Miami, USA, October 23-28, 1999.
2. 6th National Parkinson Foundation International Symposium on Parkinson's disease Research, Miami, U.S.A, October 22-23, 1999.

Fellowship, INSERM U289, Hôpital de la Salpetrière, Paris, France; September 1998 - February 1999. Project: Effects of levodopa administration in rats with intrastriatal 6-hydroxidopamine induced lesions.

Young Investigator Award, University of Buenos Aires -1998- DOPAMINE ´98, Strasbourg, France, July 22-25, 1998, Satellite Symposium of International Union of Pharmacology (IUPHAR) Congress in Munich. Abstract: Dopamine p98.

Fundación A. Roemmers Grant to Biomedical Research (1998). Project: ¿Juegan las neurotrofinas un rol en las modificaciones de largo plazo de la función de los ganglios de la base que ocurren en la enfermedad del Parkinson?

Fundación Antorchas Grant, Buenos Aires, Argentina (1995-1997). Project: Bases neurales de las acciones del estriado y el núcleo subtalámico sobre la sustancia negra

Professional Societies:

International Basal Ganglia Society (IBAGS)
Society for Neuroscience (SFN)
Sociedad Española de Neurociencia (SENC, Spain Society for Neuroscience)
Société des Neurosciences (France Society for Neuroscience)
The Federation of European Neuroscience Societies (FENS)

Conference and Symposia:

"Impact of slow cortical rhythms on basal ganglia output nuclei activity in experimental parkinsonism", University Victor Segalen, CNRS UMR-5541, Bordeaux, France, July 10th, 2002.

"Fisiopatología de la Enfermedad de Parkinson: Estudio electrofisiológico en un modelo animal (ratas 6-OHDA) de parkinsonismo", II Taller de Neurociencias, Conferencia para Jóvenes Investigadores, Vaquerias, Córdoba, Argentina, April 29th, 2000. http://www.ochava.dna.uba.ar/neuro/tn2000

"Selective increase of Nurr1 mRNA expression in D2 dopamine receptor deficient mice midbrain dopaminergic neurons", Hôpital de la Salpêtrière, INSERM U289, Paris, France, February 17th, 1999.

"Substantia nigra pars reticulata units of 6-hydroxydopamine lesioned rats differ in their response to striatal dopamine receptors stimulation and subthalamic nucleus lesions", Hôpital de la Salpêtrière, INSERM U289, Paris, December 16th, 1998.

Publications:

11. - Tseng K.Y., Riquelme L.A., Murer M.G. Role of D1 dopamine receptor in controlling the flow of cortical activity through the striatal medium-spiny neurons in experimental parkinsonism (under review).

10. - Tseng K.Y., Riquelme L.A., Murer M.G., Impact of cortical rhythms on basal ganglia output nuclei activity in experimental parkinsonism: Role of the striatum and the subthalamic nucleus. Advances in Behavioral Biology (vol. 52), The Basal Ganglia VII 2002, p445-454; Edited by Nicholson LFB and Faull RLM, Kluwer Academic/Plenum Press.

9. - Murer M.G., Tseng K.Y., Kasanetz F., Belluscio M., Riquelme L.A. Brain oscillations, medium spiny neurons and dopamine (Commentary). Cellular and Molecular Neurobiology 2002; 22 (5/6): in press

8. - Tseng K.Y., Kasanetz F., Kargieman L., Riquelme L.A., Murer M.G. Cortical slow oscillatory activity is reflected in the membrane potential and spike trains of striatal neurons in rats with chronic nigrostriatal lesions. The Journal of Neuroscience 2001; 21(16): 6430-6439.

7. - Tseng K.Y., Kasanetz F., Kargieman L., Pazo J.H., Murer M.G., Riquelme L.A. Subthalamic nucleus lesions reduce low frequency oscillatory firing of substantia nigra pars reticulata neurons in a rat model of Parkinson´s disease. Brain Research 2001; 904: 93-103.

6. - Tseng K.Y., Riquelme L.A., Belforte J.E., Pazo J.H., Murer M.G. Substantia nigra pars reticulata units of 6-hydroxydopamine lesioned rats differ in their response to striatal dopamine receptors stimulation and subthalamic nucleus lesions. European Journal of Neuroscience 2000; 12(1): 247-256.

5. - Tseng K.Y., Roubert C., Do L., Rubinstein M., Kelly M., Grandy D.K., Low M.J., Gershanik O.S., Murer M.G., Giros B., Raisman-Vozari R. Selective increase of Nurr1 mRNA expression in D2 dopamine receptor deficient mice midbrain dopaminergic neurons. Molecular Brain Research 2000; 80: 1-6.

4. - Murer M.G., Dziewczapolski G., Salin P., Vila M., Tseng K.Y., Ruberg M., Rubinstein M., Kelly M., Low M.J., Hirsch E., Raisman-Vozari R., Gershanik O.S. The indirect basal ganglia pathway exhibits parkinsonian-like changes in dopamine D2 receptor deficient mice. Neuroscience 2000; 99: 643-650.

3. - Murer M.G., Riquelme L.A., Tseng K.Y., Pazo J.H. Substantia nigra pars reticulata single unit activity in normal and 6-OHDA lesioned rats: effects of intrastriatal apomorphine and subthalamic lesions. Synapse 1997; 27: 278-293.

2. - Murer M.G., Riquelme L.A., Tseng K.Y., Cristal A., Santos J., Pazo J.H. D1-D2 Dopamine receptor interaction: an in vivo single unit electrophysiological study. Neuroreport 1997; 08: 783-787.

1. - Murer M.G., Tseng K.Y., Sinay V., Peñalva R., Armando I., Pazo J.H. Turning behavior induced by microinjections of glutamate receptor antagonists into the substantia nigra of the rat. Synapse 1996; 24: 147-155.

Manuscript in preparation:

Tseng K.Y., Murer M.G., Riquelme L.A. Impact of chronic nigrostriatal lesions on cortico-striatal synaptic response in vivo: implications for Parkinson's disease.

Tseng K.Y., Kargieman L., Gacio S., Riquelme L.A., Murer M.G. Impact of chronic nigrostriatal lesions in cortico-basal ganglia output nuclei synchronous activity: implications for Parkinson's disease.

Abstracts and Poster papers:

26. - Tseng K.Y., O'Donnell P., D2 DA receptors attenuate AMPA-mediated response in prefrontal cortical (PFC) pyramidal neurons in slices. 32nd Annual Meeting of the Society for Neuroscience, Orlando 2-7 November/2002, U.S.A. Abstract: SFN 2002; vol 28, P336.4.

25. - Murer M.G., Riquelme L.A., Tseng K.Y., In vivo evidence for a role of dopamine and D1 dopamine receptor (DAR) in modulating the flow of cortical activity through striatal medium-spiny neurons (MSNs) in experimental parkinsonism. 32nd Annual Meeting of the Society for Neuroscience, Orlando 2-7 November/2002, U.S.A. Abstract: SFN 2002; vol 28, P663.1.

24. - Tseng K.Y., Riquelme L.A., Murer M.G., Role of D1 dopamine receptor (DAR) in controlling the flow of cortical activity through the striatal medium-spiny neurons (MSNs) in experimental parkinsonism. Third Forum of European Neuroscience (FENS, The Federation of European Neuroscience Societies), 13-17 July/2002, Palais des Congres, Paris, France. Abstract: in press

23. - Tseng K.Y., Riquelme L.A., Kasanetz F., Kargieman L., Murer M.G., Nigrostriatal lesion alters the two-state spontaneous membrane potential fluctuations of neostriatal spiny neurons. Seventh International Triennial Meeting of International Basal Ganglia Society (IBAGS VII), Waitangi, Bay of Islands, New Zealand, February 11-15, 2001. Abstract: p49. Poster award IBAGS VII 2001.

22. - Kasanetz F., Tseng K.Y., Riquelme L.A., Murer M.G. Disruption of the bistable membrane potential of striatal spiny neurons during cortical desynchronization. 31st Annual Meeting of the Society for Neuroscience, San Diego 10-15 November/2001, U.S.A. Abstract: SFN 2001; vol 27, P67.4.

21. - Tseng K.Y., Roubert C., Do L., Rubinstein M., Kelly M., Grandy D.K., Low M.J., Agid Y., Gershanik O.S., Giros B., Murer M.G., Raisman-Vozari R. Selective increase of Nurr1 mRNA expression in mesencephalic dopaminergic neurons of D2 dopamine receptor deficient mice. 30th Annual Meeting of the Society for Neuroscience, New Orleans 4-9 November/2000, U.S.A. Abstract: SFN 2000; vol 26, 1162 (P436.9).

20. - Tseng K.Y., Riquelme L.A., Kasanetz F., Kargieman L., Pazo J.H., Murer M.G., Influence of the nigrostriatal system on the spontaneous membrane potential fluctuations of neostriatal spiny neurons. XXXII° Reunión Anual de la Asociación Argentina de Farmacología Experimental (SAFE), Universidad Nacional de Cuyo, Mendoza 15-18 de Noviembre. Biocell 2000; 24 (suppl.): 48 (P53).

19. - Tseng K.Y., Riquelme L.A., Kasanetz F., Pazo J.H., Murer M.G.,The low frequency oscillatory (LFO) firing of substantia nigra pars reticulata (SNr) units from hemiparkinsonian rats is modulated by striatal D1 dopamine receptors. XXXII° Reunión Anual de la Asociación Argentina de Farmacología Experimental (SAFE), Universidad Nacional de Cuyo, Mendoza 15-18 de Noviembre. Biocell 2000; 24 (suppl.): 57 (P89).

18. - Kasanetz F., Tseng K.Y., Kargieman L., Riquelme L.A., Murer M.G., Spreading of slow cortical rhytms to the basal ganglia in experimental parkinsonism: role of the NMDA receptors. XXXII° Reunión Anual de la Asociación Argentina de Farmacología Experimental (SAFE), Universidad Nacional de Cuyo, Mendoza 15-18 de Noviembre. Biocell 2000; 24 (suppl.): 57 (P90).

17. - Santangelo A.M., Tseng K.Y., Riquelme L.A., Belforte J.E., Murer M.G., Pazo J.H., Chronic lesions of the nigrostriatal pathway increase the proportion of low frequency oscillatory units in the subthalamic nucleus. XXXII° Reunión Anual de la Asociación Argentina de Farmacología Experimental (SAFE), Universidad Nacional de Cuyo, Mendoza 15-18 de Noviembre. Biocell 2000; 24 (suppl.): 53 (P75).

16. - Kasanezt F., Tseng K.Y., Riquelme L.A., Gershanik O., Raisman-Vozari R., Murer M.G., Expresion y efectos del factor neurotrofico derivado del cerebro en un modelo animal de la enfermedad de Parkinson. II Taller de Neurociencias, Vaquerias, Córdoba 27-30 de Abril de 2000. http://www.ochava.dna.uba.ar/neuro/tn2000

15. - Tseng K.Y., Delfino M., Ferrario J., Douhou A., Agid Y., Murer M.G., Raisman-Vozari R., Gershanik O.S., Absence of toxicity of oral levodopa for injured midbrain dopamine neurons. 29th Annual Meeting of the Society for Neuroscience, Miami 23-28 October/1999, U.S.A. Abstract: SFN 1999; vol 25, 2087 (P831.1).

14. - Tseng K.Y., Murer M.G., Roubert C., Dzwieczapolski G., Agid Y., Gershanik O.S., Giros B., Raisman-Vozari R., Chronic levodopa increases the expression of Nurr1 mRNA in the ventral mesencephalon of rats with moderate nigrostriatal lesions. 6th National Parkinson Foundation International Symposium on Parkinson's Disease Research, Miami 22-23 October/1999, U.S.A. -P05.

13. - Tseng K.Y., Delfino M., Ferrario J., Douhou A., Agid Y., Murer M.G., Raisman-Vozari R., Gershanik O.S., Absence of toxicity of oral levodopa for injured midbrain dopamine neurons. 6th National Parkinson Foundation International Symposium on Parkinson's Disease Research, Miami 22-23 October/1999, U.S.A. -P25.

12. - Raisman-Vozari R., Tseng K.Y., Douhou A., Ferrario J., Delfino M., Agid Y., Murer M.G., Gershanik O.S., Absence de toxicité de la L-Dopa au niveau des terminaisons nerveuses dopaminergiques dans un modèle de dégénérescence induite par l'injection intrastriatale de 6-OHDA. 4º Colloque de la Société Française des Neurosciences, Marseille 25-28 mai/1999, France.

11. - Tseng K.Y., Riquelme L.A., Belforte J.E., Pazo J.H., Murer M.G., Subthalamic lesions reduce striatal D2 receptor induced responses of substantia nigra pars reticulata single units in 6-OHDA lesioned rats. DOPAMINE ´98, Strabourg, France, July 22-25, 1998 / Satelite Symposium of the IUPHAR Congress in Munich. Abstract: Dopamine, p98.

10. - Tseng K.Y., Delfino M., Ferrario J., Douhou A., Agid Y., Murer M.G., Raisman-Vozari R., Gershanik O.S., La Levodopa administrada por via oral no produce efecto tóxico sobre neuronas dopaminérgicas mesencefálicas en degeneración en un modelo animal de la enfermedad de Parkinson. XXXVI Congreso Argentino de Neurología, Sociedad Neurológica Argentina-Filial de la Federación Mundial de Neurología, San Juan, 21 al 26 de Septiembre de 1999. Revista Neurológica Argentina 1999; 24: 30.

9. - Ferrario J., Delfino M., Dzwieczapolski G., Tseng K.Y., Raisman-Vozari R., Murer M.G., Gershanik O.S., Aumento de la unión del I125-sulpirida en el núcleo subtalámico de ratas con lesión nigroestriatal.XXI Reunión de la SAFE, Mar del Plata, Noviembre de 1999. Medicina 1999; 59: 654.

8. - Santangelo A.M., Belforte J.E., Tseng K.Y., Pazo J.H., Respuesta del núcleo subtalámico a la estimulación de los receptores dopaminérgicos estriatales. XLIII Reunión Científica Anual de la SAIC, Mar del Plata, Noviembre de 1998. Medicina 1998; 58: 633.

7. - Tseng K.Y., Riquelme L.A., Pazo J.H., Murer M.G., Efecto de los agonistas D1 y D2 sobre la actividad neuronal unitaria de la sustancia negra reticulada en ratas 6-OHDA. XLII Reunión Científica Anual de la SAIC, Mar del Plata, Diciembre de 1997. Medicina 1997; 57(Supl. IV): 81.

6. - Tseng K.Y., Riquelme L.A., Pazo J.H., Murer M.G., Cambio del patrón de descarga de las neuronas tipo-salvas de la sustancia negra reticulada de ratas 6OHDA inducido por apomorfina. XLII Reunión Científica Anual de la SAIC, Mar del Plata, Diciembre de 1997. Medicina 1997; 57(Supl. IV): 82.

5. - Tseng K.Y., Riquelme L.A., Murer M.G., Pazo J.H., Influencia del N. subtalámico sobre la actividad neuronal unitaria de la sustancia negra reticulada en ratas 6-OHDA. XLI Reunión Científica Anual de la SAIC, Paraná, Entre Ríos, Noviembre de 1996. Medicina 1996; 56: 615.

4. - Tseng K.Y., Murer M.G., Riquelme L.A., Pazo J.H., Influencia del núcleo subtalámico sobre la actividad neuronal de la sustancia negra reticulada. XXVIII Reunión de la SAFE, Paraná, Entre Ríos, Noviembre de 1996. Acta Physiol. et Pharmacol. Latin. 1996; 46: 26.

3. - Murer M.G., Riquelme L.A., Tseng K.Y., Cristal A., Santos J., Pazo J.H., Estudio electrofisiológico del sustrato neural de la interacción entre receptores dopaminérgicos D1 y D2. XL Reunión Científico Anual de la SAIC, Mar del Plata, Noviembre de 1995. Medicina 1995; 55: 558.

2. - Murer M.G., Tseng K.Y., Armando I., Pazo J.H., Acción tónica del núcleo subtalámico sobre los receptores NMDA localizados en la pars reticulada de la sustancia negra. XXVII Reunión Anual de la SAFE, Buenos Aires, Noviembre de 1995. Acta Physiol. et Pharmacol. Latin. 1995; 45: 231.

1. - Murer M.G., Tseng K.Y., Sinay V., Peñalva R., Armando I., Pazo J.H., Comportamineto rotatorio inducido por microinyecciones de antagonistas glutamatérgicas en la sustancia negra. 10º Congreso Científico de la Federación Latinoamericana de Estudiantes de Medicina, Buenos Aires, 24-28 de Julio de 1995.