Patricio O'Donnell



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Patricio O'Donnell, MD, PhD

CURRICULUM VITAE

Date and Place of Birth: August 27, 1957 in Buenos Aires, Argentina

Citizenship: USA, Argentine

Education:
University of Buenos Aires, March 1976 - December 1982
Buenos Aires, Argentina. M.D.: June 1983

Hospital Italiano de Buenos Aires, May 1983 - December 1984
Residency in Internal Medicine (first two years of a four-year program)

University of Buenos Aires, March 1985 - May 1990
Dept. of Physiology, School of Medicine Ph.D.: May 1990
Academic Appointments:
Professor May 2003 - present
Center for Neuropharmacology & Neuroscience, Albany Medical College

Associate Professor February 2000 – May 2003
Center for Neuropharmacology & Neuroscience, Albany Medical College

Assistant Professor June 1997-January 2000
Departments of Pharmacology & Neuroscience, and
Neurology, Albany Medical College

Research Assistant Professor July 1995 - May 1997
Department of Neuroscience, University of Pittsburgh

Research Associate September 1990 - June 1995
Department of Neuroscience, University of Pittsburgh

Jefe de Trabajos Prácticos (Instructor / Lecturer) August 1986 - December 1991
Department of Physiology, neurophysiology group
School of Medicine, University of Buenos Aires, Argentina.

Honors and Awards:
Doctoral Fellowship, Argentine National Research Council (CONICET) May 1985 - August 1990
Travel Grant, IBRO, for 2nd World Congress of Neuroscience August 1987
Prize "Facultad de Medicina 1990" to best basic doctoral thesis. December 1991
School of Medicine, University of Buenos Aires.
Travel Award, Center for Neuroscience, University of Pittsburgh April 1993
for International Congress on Schizophrenia Research.
Young Scientist Award, Seventh Biennial Winter Workshop on Schizophrenia January 1994
Postdoctoral fellow Award for Excellence in Neuroscience Research, June 1994
Pittsburgh Neuroscience Society
Young Investigator Award, International Congress on Schizophrenia Research April 1995
NARSAD Young Investigator Award March 1995
1998 Wiggers Fellowship, Albany Medical College April 1998
Gordon Research Conference on Catecholamines Travel Fellowship July 1999
Travel Fellowship for 2000 Winter Conference on Brain Research January 2000
NARSAD Independent Investigator Award (Wodecroft Investigator) September 2001
Elected to Membership in American College of Neuropsychopharmacology 2001
NARSAD Independent Investigator Award September 2003

Research Support:
current:

National Institute of Mental Health (O’Donnell) 1997-2007
“Electrophysiology of the prefrontal cortex” (RO1 MH57683)
(Total direct costs years 6-9: $ 832,500)

National Institute of Mental Health (O’Donnell) 2000-2005
“Information processing in the nucleus accumbens” (RO1 MH60131)
(Total direct costs: $ 825,000)

National Institute of Mental Health / Fogarty International Center (O’Donnell) 2003-2005
“Cortical control of striatal cell activity” (RO3 TW006282)
(Total direct costs: $ 96,000)

National Institute of Drug Abuse (O’Donnell) 2001-2006
“Electrophysiology of behavioral sensitization” (RO1 DA14020)
(Total direct costs: $ 800,000)

NARSAD Independent Investigator Award (O’Donnell) 2003-2005
“Physiological changes in animals with a transient neonatal hippocampal inactivation” ($100,000)

National Institute of Mental Health (Sesack) 2003-2008
“Afferent Regulation of VTA Dopamine Neuron Populations” (RO1 MH67937)
(subcontract on grant; total direct costs: $ 243,121)

National Science Foundation (O’Donnell) 2004-2007
“US-France Cooperative Research: Electrophysiological studies of dopamine in the striatum” ($9,800)

past:
Scottish Rite Schizophrenia Research Program (Grace) 1992-1994
“Modulation of Dye Coupling in Nucleus Accumbens by
Dopamine Receptor Agonists and Antagonists” ($ 67,561)

Tourette’s Syndrome Association Permanent Research Fund (O’Donnell) 1995-1997
“Dopaminergic Effects on the Integration of Motor- and Affective-
related Inputs to the Nucleus Accumbens” ($ 49,356)

NARSAD Young Investigator Award (O’Donnell) 1995-1997
“Dopaminergic Control of the Hippocampal Gating of
Prefrontal Cortical Throughput in the Nucleus Accumbens” ($ 57,927)

NPS Allelix Corp. (O’Donnell) 2000–2001
“In vivo electrophysiological characterization of glycine transporter 1 inhibitors
in the rat” (Total direct costs: $ 64,412)

NARSAD Independent Investigator Award (O’Donnell) 2001-2003
“Electrophysiology of Mesocorticolimbic Systems” ($ 99,320)

Professional activities:
Physician, Centro Medicus de Diagnóstico, October 1986 - July 1990
Buenos Aires, Argentina

Member of the Board (“Consejo Directivo”), March 1988 - February 1990
School of Medicine, University of Buenos Aires; elected in representation of the School’s alumni.

Editorial Advisory Board: Journal of Pharmacology & Experimental Therapeutics 1998-present

Co-Director, Neuroscience I course (for 1st year medical students) Albany Medical College 2001- present

Member, NMB Study Section (formerly IFCN-1), NIH 2002-2006
Ad-hoc member, MDCN-5 Study Section, NIH. October 2000
Ad-hoc member, IFCN-3 Study Section, NIH June 2001
Integrative Neuroscience Initiative on Alcoholism Review Panel, NIH August 2001
Ad-hoc member, IFCN-1 Study Section, NIH October 2001, February 2002, June 2002
Ad-hoc member, BDCN-2 Study Section, NIH February 2002
Conte Centers Review Panel ZMH1 BRB PO5, NIMH March 2004

Associate Editor: The Journal of Neuroscience 2003-present

Board of Directors, Winter Conference on Brain Research 2003-2006

Ad-hoc reviewer: American Journal of Physiology, Behavioral and Brain Sciences, Behavioral and Cognitive Neuroscience Reviews, Behavioral Brain Research, Biological Psychiatry, Brain Research, Cerebral Cortex, European Journal of Neuroscience, Journal of Neuroscience Research, Neurocomputing, Neuroimage, Neuropharmacology, Neuropsychopharmacology, Neuroscience, Neuroscience Letters, PNAS, Progress in Neurobiology; Psychobiology, Schizophrenia Bulletin, Synapse, Trends in Neuroscience.

Credentials Committee Member, American College of Neuropsychopharmacology 2004-2005

Trainees:
Jennifer M. Greene, M.S. (Graduate Student: 1997-2001); Jian Wang, Ph.D. (postdoc, 1998-2001); Yvette M. Peters, Ph.D. (Graduate Student, 1998-2004); Yukiori Goto, PhD (Graduate Student, 1999-2003); Anne Marie Brady, Ph.D. (postdoc, 2000-present); Kuei-Yuan Tseng, MD,PhD (postdoc, 2001-present); Stephen Sammut, Ph.D. (postdoc, 2002-present); Jonathan Dilgen (Graduate Student, 2003-present); Kathy Toreson (Graduate Student, 2003-present); Marianne Benoit-Marand (postdoc, 2003-present).

Professional societies:
American Association for the Advancement of Sciences, American College of Neuropsychopharmacology, European Behavioral Pharmacology Society, International Basal Ganglia Society, International Brain Research Organization (IBRO), Society for Neuroscience, Society of Biological Psychiatry.

Invited presentations and symposia:
4th International Congress on Schizophrenia Research, Colorado Springs, CO April 1993
5th International Congress on Schizophrenia Research, Hot Springs, VA April 1995
X Annual retreat, Department of Neuroscience University of Pittsburgh, Johnstown, PA June 1995
Department of Anatomy and Cell Biology, Kansas University Medical Center, Kansas City, KS October 26, 1995
Department of Pharmacology, Baylor College of Medicine, Houston, TX June 13, 1996
Department of Pharmacology and Neuroscience, Albany Medical College, Albany, NY September 19, 1996
Eighth Annual NARSAD Scientific Symposium, New York, NY October 12,1996
Hudson-Berkshire chapter of the Society for Neuroscience, SUNY Albany, NY February 2, 1998
New York Academy of Science Symposium: Advancing from the ventral striatum to the extended
Amygdala: Implications for Neuropsychiatry and Drug Abuse, Charlottesville, VA October 1998
32nd Winter Conference on Brain Research, Snowmass, CO January 1999
Tenth Annual Spring Brain Conference, Sedona, AZ March 1999
Center for Molecular and Behavioral Neuroscience, Rutgers, The State University of New Jersey April 8, 1999
Dept. Physiology, School of Medicine, Universidad de Buenos Aires, Argentina September 1, 1999
Institute of Genetics and Molec. Biol. (INGEBI), Universidad de Buenos Aires, Argentina September 2, 1999
Neuroscience Grand Rounds, Dept Neurology, Albany Medical Center March 9, 2000
Neurodegenerative Disorders: Common Molecular Mechanisms, Tobago, Trinidad & Tobago April 2000
Behavioral Neuroscience Colloquium, The College of St. Rose, Albany, NY April 27, 2000
INSERM U289, Hôpital La Pitié-Salpetrière, Paris, France November 24, 2000
Seventh International Basal Ganglia Society Meeting, Bay of Islands, New Zealand February 2001
Dept. Psychology, Ohio State University, Columbus, OH November 28, 2001
35th Winter Conference on Brain Research, Snowmass, CO January 2002
Dept. Psychiatry, Yale University School of Medicine, New Haven, CT March 11, 2002
4th Argentine Neuroscience Workshop, Valle Hermoso, Cordoba, Argentina April 2002
7th Neurodegenerative Disorders: Common Molecular Mechanisms, Montego Bay, Jamaica April 2002
Dept. Psychiatry, Univ. Texas Southwestern Medical Center, Dallas, TX April 30, 2002
Institute of Neuroscience, University of Pennsylvania, Philadelphia, PA May 15, 2002
57th Society of Biological Psychiatry meeting, Philadelphia, PA May 2002
Undergraduate Program in Neuroscience, SUNY Albany, NY June 14, 2002
Dopamine 2002, Portland, OR July 2002
McLean Hospital, Harvard Medical School, Belmont, MA September 17, 2002
Dept. Physiology, Northwestern University School of Medicine, Chicago, IL October 8, 2002
Dept. Pharmacology, Boston University School of Medicine, Boston, MA October 23, 2002
Merck Research Laboratories, King of Prussia, PA October 29, 2002
41st ACNP Meeting, San Juan, PR December 12, 2002
36th Winter Conference on Brain Research, Snowbird, UT January 2003
International Congress on Schizophrenia Research, Colorado Springs, CO March 2003
Dept. Psychology, University of Connecticut, Storrs, CT April 18, 2003
Dept. Physiology & Neuroscience, Medical University of South Carolina, Charleston, SC April 25, 2003
Sensory-Motor Systems Workshop, Mathematical Biosciences Institute, Ohio State Univ. June 12, 2003
Gordon Conference on Catecholamines, Oxford, UK August 2003
Hudson-Berkshire chapter of the Society for Neuroscience, SUNY Albany, NY September 15, 2003
33rd Annual Meeting, Society for Neuroscience, New Orleans, LA November 2003
Department of Neuroscience, University of New Mexico, Albuquerque, NM November 20, 2003
37th Winter Conference on Brain Research, Copper Mountain. CO January 2004
Dept. Psychology, Univ. North Carolina, Chapel Hill, NC February 10, 2004
Ernest Gallo Clinic and Research Center, UCSF, San Francisco, CA March 10, 2004

Chaired panels and symposia:
The nucleus accumbens as an information integrator. P. O’Donnell, P.W. Kalivas, N.R. Swerdlow
& D.S. Zahm, 30th Winter Conference on Brain Research, Breckenridge, CO January 1997
Parallel loops in basal ganglia circuits: Segregated or interconnected? P. O’Donnell, H. Groenewegen,
Y. Smith & C.R. Gerfen, 31st Winter Conference on Brain Research, Snowbird, UT January 1998
Dopamine: Is it excitatory, inhibitory, neither or both? P. O’Donnell, M.S. Levine, R. Malenka
& G. Snyder. 33rd Winter Conference on Brain Research, Breckenridge, CO January 2000
Dopaminergic projections and neural ensembles in prefrontal cortical-ventral striatal loops. P. O’Donnell
A. Grace, W. Schultz & L. Peoples. 34th Winter Conference on Brain Research, Steamboat Springs January 2001
Afferent modulation of mesoaccumbens function. M. Marinelli, K.A. Cunningham, F.J. White & A. Kelley
1st Joint Meeting of Eur. Brain & Behaviour Society and European Behavioral Pharmacology Society
Marseille, France September 2001
Animal models of schizophrenia: Are we there yet? A. Grace, L. Peoples, M. Geyer & P. O’Donnell
57th Society of Biological Psychiatry meeting, Philadelphia, PA May 2002
Spiraling limbic-to-motor information flow in cortico-basal ganglia circuits. S. Haber, P. O’Donnell,
W. Schultz & M. Laruelle. ACNP 41st Annual Meeting, San Juan, PR December 2002

Publications
Peer-reviewed articles:

32. Tseng, KY, and O’Donnell, P. Dopamine-glutamate interactions controlling prefrontal cortical pyramidal cell excitability involve multiple signaling mechanisms. Submitted.

31. Tseng, K.Y. and O’Donnell, P. Postpubertal emergence of prefrontal cortical oscillations induced by D1-NMDA co-activation. Cerebral Cortex (in press).

30. Peters, Y., Barnhardt, N.E. and O’Donnell, P. Prefrontal cortical up states are synchronized with ventral tegmental area activity. Synapse 52 (2004) 143-152.

29. Brady, A.M. and O’Donnell, P. Mesolimbic modulation of prefrontal cortical input to nucleus accumbens neurons in vivo. Journal of Neuroscience 24 (2004) 1040-1049.

28. Goto Y. and O’Donnell, P. Prefrontal cortical lesion reverses abnormal mesoaccumbens response in an animal model of schizophrenia. Biological Psychiatry 55 (2004) 172-176.

27. O’Donnell, P. Dopamine gating of forebrain neural ensembles. European Journal of Neuroscience 17 (2003) 429-435.

26. Goto, Y. and O’Donnell, P. Delayed mesolimbic system alteration in a developmental animal model of schizophrenia. Journal of Neuroscience 22 (2002) 9070-9077.

25. Goto, Y. and O’Donnell, P. Timing-dependent limbic-motor synaptic integration in the nucleus accumbens. Proceedings of the National Academy of Sciences 99 (2002) 13189-13193.

24. O’Donnell, P., Lewis, B.L., Weinberger, D.R., and Lipska, B.K. Neonatal hippocampal damage alters electrophysiological properties of prefrontal cortical neurons in adult rats. Cerebral Cortex 12 (2002) 975-982.

23. Goto, Y. and O’Donnell, P. Network synchrony in the nucleus accumbens. Journal of Neuroscience 21 (2001) 4498-4504.

22. Goto, Y. and O’Donnell, P. Synchronous activity in the hippocampus and nucleus accumbens in vivo. Journal of Neuroscience 21 (2001) RC131.

21. Wang, J. and O’Donnell, P. D1 dopamine receptors potentiate NMDA-mediated excitability increase in rat prefrontal cortical pyramidal neurons. Cerebral Cortex 11 (2001) 452-462.

20. Lewis, B.L. and O’Donnell, P. Ventral tegmental area afferents to the prefrontal cortex maintain membrane potential ‘up’ states in pyramidal neurons via D1 dopamine receptors. Cerebral Cortex 10 (2000) 1168-1175.

19. O’Donnell, P. Ensemble coding in the nucleus accumbens. Psychobiology 27 (1999) 187-197.

18. O’Donnell, P., Greene, J., Pabello, N., Lewis, B.L. and Grace, A.A. Modulation of cell firing in the nucleus accumbens. In: Annals of the New York Academy of Science, 877 (1999) 157-175.

17. Carr, D.B., O’Donnell, P., Card, J.P. and Sesack, S.R. Dopamine terminals in the rat prefrontal cortex synapse on pyramidal cells that project to the nucleus accumbens. Journal of Neuroscience 19 (1999) 11049-11060.

16. O’Donnell, P. and Grace, A.A. Dysfunction in multiple interrelated systems as the neurobiological bases of schizophrenic symptom clusters. Schizophrenia Bulletin 24 (1998) 267-283

15. O’Donnell, P. and Grace, A.A. Phencyclidine interferes with the hippocampal gating of nucleus accumbens neuronal activity in vivo. Neuroscience 87 (1998) 823-830.

14. O’Donnell, P., Lavín, A., Enquist, L.W., Grace, A.A., and Card, J.P. Interconnected parallel circuits between rat nucleus accumbens and thalamus revealed by retrograde transynaptic transport of pseudorabies virus. Journal of Neuroscience 17 (1997) 2143-2167.

13. O’Donnell, P. and Grace, A.A. Cortical afferents modulate striatal gap junction permeability via nitric oxide. Neuroscience 76 (1997) 1-5.

12. O’Donnell, P. and Grace, A.A. Dopaminergic reduction of excitability in nucleus accumbens neurons recorded in vitro. Neuropsychopharmacology 15 (1996) 87-97.

11. O’Donnell, P. and Grace, A.A. Different effects of subchronic clozapine and haloperidol on dye coupling between neurons in the rat striatal complex. Neuroscience 66 (1995) 763-767.

10. O’Donnell, P. and Grace, A.A. Synaptic interactions among excitatory afferents to nucleus accumbens neurons: Hippocampal gating of prefrontal cortical input. Journal of Neuroscience 15 (1995) 3622-3639.

9. O’Donnell, P. and Grace, A.A. Tonic D2-mediated attenuation of cortical excitation in nucleus accumbens neurons recorded in vitro. Brain Research 634 (1994) 105-112.

8. O’Donnell, P. and Grace, A.A. Dopaminergic modulation of dye coupling between neurons in the core and shell region of the nucleus accumbens. Journal of Neuroscience 13 (1993) 3456-3471.

7. O’Donnell, P. and Grace, A.A. Physiological and morphological properties of accumbens core and shell neurons recorded in vitro. Synapse 13 (1993) 135-160.

6. Pazo, J.H., O’Donnell, P. and Murer, M.G. Spontaneous and evoked activity of the caudate neurons to central and peripheral stimuli after lesions. Neuroscience 50 (1992) 387-393.

5. O’Donnell, P., Murer, M.G. and Pazo, J.H. Central and peripheral modulation of spontaneous neuronal activity in the caudate nucleus. Neuroscience 33 (1989) 543-548.

4. Pazo, J.H., O’Donnell, P., Murer, M.G., Gonzalez, M. and Pia, A. Spinal cord substrate of the turning behavior induced by unilateral lesion of the entopeduncular nucleus. International Journal of Neuroscience 34 (1987) 27-33.

3. Pazo, J.H., Gomez-Gonzalez, M., Tumilasci, O.R., O’Donnell, P. and Murer, M.G. The sialagogue response of striatal dopamine receptors to L-DOPA is not influenced by castration or chronic estrogen treatment. Brain Research Bulletin 16 (1986) 1-4.

2. Pazo, J.H., Dvorkin, M.A. and O’Donnell, P. Effects of spinal cord sections on circling behavior of rats. Comunicaciones Biológicas 1 (1983) 389-394.

1. Pazo, J.H., Medina, J.H., O’Donnell, P. and Dvorkin, M.A. Study of the neural basis of circling behavior induced by L-DOPA in lesioned entopeduncular cats. Brain Research 233 (1982) 337-345.

In preparation:

Peters, Y., O’Donnell, P, and Carelli, R.M. Changes in phasic activity from prefrontal cortical neurons are closely time-locked with aspects of goal directed behavior for water reinforcement.

Book Chapters:

15. O’Donnell, P. Neurophysiological effects of atypical antipsychotic drugs. In: Atypical Antipsychotics: A Bench to Bedside Perspective for Clinicians. J.G. Csernansky, M. Lauriello, Eds. Marcel Dekker, Inc., New York (2004) 43-60.

14. Goto, Y, Tseng, K.Y., Lewis, B.L. and O’Donnell, P. Dopamine modulation of prefrontal cortical neural ensembles and synaptic plasticity: Potential involvement in schizophrenia. In: Prefrontal Cortex: from Synaptic Plasticity to Cognition. S. Otani, Ed. Kluwer Academic Publishers, (2004) 61-84.

13. O’Donnell, P. Génesis y transmisión del impulso nervioso. In: Best & Taylor. Bases Fisiológicas de la Práctica Médica. 13 edition. M. Dvorkin, D. Cardinali, Eds. Editorial Panamericana, (2003) 817-842.

12. O’Donnell, P. Funciones cerebrales superiores. In: Best & Taylor. Bases Fisiológicas de la Práctica Médica. 13 edition. M. Dvorkin, D. Cardinali, Eds. Editorial Panamericana, (2003) 1047-1060.

11. Brady, A.M., Glick, S.D. and O’Donnell, P. Changes in electrophysiological properties of nucleus accumbens neurons depend on the extent of behavioral sensitization to chronic methamphetamine. In: Glutamate and Disorders of Cognition and Motivation. B. Mogghadam and M.E. Wolf, Eds. New York Academy of Sciences, Vol 1003 (2003) 358-363.

10. Lewis, B.L. and O’Donnell, P. Blockade of the GlyT1 glycine transporter prolongs response to VTA stimulation in nucleus accumbens neurons. In: Glutamate and Disorders of Cognition and Motivation. B. Mogghadam and M.E. Wolf, Eds. New York Academy of Sciences, Vol 1003 (2003) 431-434.

9. Goto, Y. and O’Donnell, P. Altered prefrontal cortex-nucleus accumbens information processing in a developmental animal model of schizophrenia. In: Glutamate and Disorders of Cognition and Motivation. B. Mogghadam and M.E. Wolf, Eds. New York Academy of Sciences, Vol 1003 (2003) 398-401.

8. Tseng, K.Y. and O’Donnell, P. Dopamine-glutamate interactions in the control of cell excitability in medial prefrontal cortical pyramidal neurons. In: Glutamate and Disorders of Cognition and Motivation. B. Mogghadam and M.E. Wolf, Eds. New York Academy of Sciences, Vol 1003 (2003) 476-478.

7. Goto, Y. and O’Donnell, P. Hippocampal regulation of prefrontal cortex – nucleus accumbens information processing. The role of dopamine. In: The Basal Ganglia VII. L.F.B. Nicholson, R.L.M. Faull, Eds. Kluwer Academic Pub. (2002) 201-209.

6. O’Donnell, P. Dopamine and ensemble coding in the striatum and nucleus accumbens: A coincidence detection mechanism. In: The Basal Ganglia VI. A. Graybiel, M. DeLong, S. Kitai, Eds. Kluwer Academic Pub (2002) 237-244.

5. O’Donnell, P. and Grace, A.A. Disruption of information flow within cortical-limbic circuits and the pathophysiology of schizophrenia. In: Schizophrenia in a Molecular Age. C.A. Tamminga, Ed. American Psychiatric Press, Washington, DC (1999) 109-140.

4. Grace, A.A., Moore, H. and O’Donnell, P. The modulation of corticoaccumbens transmission by limbic afferents and dopamine: a model for the pathophysiology of schizophrenia. In: Catecholamines: Bridging Basic Science with Clinical Medicine (Adv. Pharmacol., vol 42). D. Goldstein, Ed. Academic Press, San Diego (1998) 721-724.

3. O’Donnell, P. and Grace, A.A. Basic physiology of antipsychotic drug action. In: Handbook of Experimental Pharmacology: Antipsychotics. J.G. Csernansky, Ed. Springer-Verlag, Berlin (1996), 163-202.

2. O’Donnell, P. and Pazo, J.H. Lateralización de las funciones cerebrales superiores. In: Fisiología Humana de B. Houssay, Tome IV: Neurofisiología. A.B. Houssay & R. Cingolani Eds. El Ateneo, Buenos Aires (1989), pp 320-326.

1. O’Donnell, P. and Pazo, J.H. Bases de la génesis y transmisión del inpulso nervioso. In: Fisiología Humana de B. Houssay, Tome IV: Neurofisiología. A.B. Houssay & R. Cingolani Eds. El Ateneo, Buenos Aires (1989), pp 1-25.

Abstracts and Poster papers:

85. Tseng, K.Y., Lewis, B.L. and O’Donnell, P. Disruption of prefrontal cortical dopamine-glutamate interactions in animals with a neonatal ventral hippocampal lesion. American College of Neuropsychopharmacology Abstracts, 167, 2003.

84. Grace, A.A., Moore, H., Onn, S. and O’Donnell, P. Gap junctions: Mediators of plasticity in response to long-term disruptions of neuronal systems. American College of Neuropsychopharmacology Abstracts, 2003. Program No. THPM24.

83. O’Donnell, P., Glick, S.D., Barnhardt, N.E., and Brady, A.M. Electrophysiology of interactions between prefrontal cortex, nucleus accumbens and ventral tegmental area in rats behaviorally sensitized to methamphetamine. Program No. 112.10. 2003 Abstract Viewer/Itinerary Planner. Washington, DC. Society for Neuroscience.

82. Goto, Y, Grace, A.A. and O’Donnell, P. Dopamine modulation of synaptic plasticity and mesocorticolimbic ensemble coding: a theoretical approach. Program No. 915.4. 2003 Abstract Viewer/Itinerary Planner. Washington, DC. Society for Neuroscience.

81. Snyder-Keller, A., Tseng, K.Y. and O’Donnell, P. Nigral inputs enhance spontaneous and cortically-driven striatal activity in organotypic co-cultures. Program No. 706.5. 2003 Abstract Viewer/Itinerary Planner. Washington, DC. Society for Neuroscience.

80. Sammut, S. and O’Donnell, P. Simultaneous in vivo local field potential and electrochemical recordings in the nucleus accumbens. Program No. 461.6. 2003 Abstract Viewer/Itinerary Planner. Washington, DC. Society for Neuroscience.

79. Tseng, K.Y. and O’Donnell, P. D1-NMDA receptor co-activation induces membrane potential oscillations resembling in vivo up states in prefrontal cortical slices from adult animals. Program No. 461.3. 2003 Abstract Viewer/Itinerary Planner. Washington, DC. Society for Neuroscience.

78. Brady, A.M. and O’Donnell, P. Stimulation of the ventral tegmental area suppresses prefrontal cortical input to nucleus accumbens neurons via D2 receptors. Program No. 461.1. 2003 Abstract Viewer/Itinerary Planner. Washington, DC. Society for Neuroscience.

77. Peters, Y.M., O’Donnell, P. and Carelli, R.M. Prefrontal cortical responses during maintenance vs. extinction of goal directed responses fro water reinforcement in rats. Program No. 321.8. 2003 Abstract Viewer/Itinerary Planner. Washington, DC. Society for Neuroscience.

76. Lewis, B.L., Tseng, K.Y., Amin, F. and O’Donnell, P. Increased metabolic activity in medial prefrontal cortex following ventral tegmental area burst stimulation in animals with a neonatal ventral hippocampal lesion. Program No. 315.16. 2003 Abstract Viewer/Itinerary Planner. Washington, DC. Society for Neuroscience.

75. Peters, Y., O’Donnell, P. and Carelli, R.M. Prefrontal cortical responses during maintenance vs. extinction of goal directed behavior for water reinforcement in rats. Behavioral Pharmacology, 2003, 14:S74.

74. O’Donnell, P, Brady, AM and Glick SD. Accumbens physiological properties are different in animals showing behavioral sensitization versus those that do not sensitize after repeated methamphetamine. Behavioral Pharmacology, 2003, 14:S57.

73. O’Donnell, P and Tseng KY. Dopamine-glutamate interactions in the prefrontal cortex: D1 gating of information processing. Schizophrenia Research 2003 60:257.

72. O’Donnell, P and Goto, Y. Timing-dependent integration of limbic and prefrontal cortical inputs in the nucleus accumbens. American College of Neuropsychopharmacology Abstracts, 2002, 80.

71. O’Donnell, P., Goto, Y. Limbic-motor coincidence detection and output selection in the nucleus accumbens. Program No. 461.9. 2002 Abstract Viewer/Itinerary Planner. Washington, DC: Society for Neuroscience, 2002. CD-ROM.

70. Himmelheber, A.M., Glick, S.D. and O’Donnell, P. Electrophysiology of nucleus accumbens neurons after chronic administration of methamphetamine. Program No. 461.8. 2002 Abstract Viewer/Itinerary Planner. Washington, DC: Society for Neuroscience, 2002. CD-ROM.

69. Goto, Y. and O’Donnell, P. Long term potentiation and its modulation by dopamine in the entorhinal cortical - prefrontal cortex and nucleus accumbens pathways. Program No. 347.15. 2002 Abstract Viewer/Itinerary Planner. Washington, DC: Society for Neuroscience, 2002. CD-ROM.

68. Tseng, K.Y. and O’Donnell, P. D2 DA receptors attenuate AMPA-mediated response in layer V prefrontal cortical (PFC) pyramidal neurons in slices. Program No. 336.4. 2002 Abstract Viewer/Itinerary Planner. Washington, DC: Society for Neuroscience, 2002. CD-ROM.

67. Peters, Y.M. and O’Donnell, P. Ventral tegmental area modulation of prefrontal cortical pyramidal neurons. Program No. 62.9. 2002 Abstract Viewer/Itinerary Planner. Washington, DC: Society for Neuroscience, 2002. CD-ROM.

66. Lewis, B.L. and O’Donnell, P. Prolonged depolarization of medial prefrontal cortical neurons following activation of dopaminergic ventral tegmental area afferents. Program No. 62.8. 2002 Abstract Viewer/Itinerary Planner. Washington, DC: Society for Neuroscience, 2002. CD-ROM.

65. Goto, Y. and O’Donnell, P. Chronic haloperidol treatment restores altered accumbens response to dopamine afferent activation in an animal model of schizophrenia. 3rd Forum of European Neurosciences, Paris, France (2002) p.276.

64. O’Donnell, P., Lewis, B.L. and Goto, Y. Functional alteration in mesocortical and mesolimbic systems in animals with a neonatal hippocampal lesion. Biological Psychiatry 51 (2002) 9S.

63. O’Donnell, P., Lewis, B.L., Weinberger, D.R. and Lipska, B.L. Neonatal hippocampal damage alters physiological response properties to VTA stimulation in the adult rat prefrontal cortex. Biological Psychiatry 51 (2002) 61S.

62. O’Donnell, P., Lewis, B.L. and Goto, Y. Mesolimbic dopamine systems are altered in an animal model of schizophrenia. 7th Neurodegenerative Disorders: Common Molecular Mechanisms, Montego Bay, Jamaica (2002) 49.

61. Goto, Y. and O’Donnell, P. Physiological abnormalities in the nucleus accumbens in an animal model of schizophrenia: in vivo electrophysiological study. EMBO-FMI Conference: Organizing the Brain: Genes, Neurons and Circuits, Monte Verita, Ascona, Switzerland (2002).

60. Peters, Y. and O’Donnell, P. Membrane potential states of prefrontal cortical pyramidal neurons correlate with local field potentials in the ventral tegmental area. 35th Winter Conference on Brain Research (2002) 37-38.

59. Himmelheber, A.M. and O’Donnell, P. Modulation of prefrontal cortex-nucleus accumbens synaptic responses by stimulation of the ventral tegmental area in vivo. 35th Winter Conference on Brain Research (2002) 35-36.

58. Goto, Y. and O’Donnell, P. Limbic-motor integration in the nucleus accumbens. 35th Winter Conference on Brain Research (2002) 27-28.

57. O’Donnell, P, Goto, Y and Himmelheber, A.M. Limbic-cortical interactions in the nucleus accumbens: in vivo intracellular studies. American College of Neuropsychopharmacology Abstracts (2001).

56. Himmelheber, A.M. and O’Donnell, P. Stimulation of the ventral tegmental area affects prefrontal cortex-nucleus accumbens synaptic responses in vivo. Soc. Neurosci. Abstr. 27 (2001) 67.14.

55. Goto, Y. and O’Donnell, P. Neonatal hippocampal lesion alters nucleus accumbens response to ventral tegmental area stimulation. Soc. Neurosci. Abstr. 27 (2001) 67.15.

54. Peters, Y.M. and O’Donnell, P. Prefrontal cortical-ventral tegmental area synchrony: simultaneous recordings in vivo. Soc. Neurosci. Abstr. 27 (2001) 729.19.

53. Lewis, B.L., Lipska, BK, Weinberger, DR, O’Donnell, P. Neonatal hippocampal damage alters physiological properties of the mesocortical system in adult rats. Soc. Neurosci. Abstr. 27 (2001) 876.14.

52. O’Donnell, P. and Goto, Y. Hippocampus-nucleus accumbens network properties: in vivo recordings. Behavioral Pharmacology 12 (2001) 71S.

51. Himmelheber, A.M. and O’Donnell, P. Effects of ventral tegmental area stimulation on synaptic responses to prefrontal cortex stimulation in nucleus accumbens in vivo. in: Monitoring Molecules in Neuroscience (W.T. O’Connor, J.P. Lowry, J.J. O’Connor, R.D. O’Neill, Eds.) University College Dublin, 2001, 213-214.

50. O’Donnell, P and Goto, Y. Hippocampal gating of nucleus accumbens neurons: simultaneous recordings from the hippocampus and accumbens. VII International Basal Ganglia Society Meeting, Waitangi, New Zealand, (2001) 20.

49. Moore, H., O’Donnell, P., and Grace, A.A. Interactions between prefrontal cortical, hippocampal, and amygdalar inputs in regulating the activity of nucleus accumbens neurons. Biological Psychiatry 49 (2001) 10S.

48. O’Donnell, P., Wang, J., Lewis, B.L., and Peters, Y.M. D1 dopamine receptors contribute to prefrontal cortical pyramidal cell excitability: in vivo and in vitro studies. American College of Neuropsychopharmacology Abstracts (2000) 203.

47. Lewis, B.L., Lipski, W.J., Weinberger, D.R., Lipska, B.K. and O’Donnell, P. A neonatal hippocampal lesion increases VTA cell firing in adult rats. Soc. Neurosci. Abstr.26 (2000) 1224.

46. Goto, Y. and O’Donnell, P. Local field potentials as indicators of membrane potential state transitions in nucleus accumbens neurons. Soc. Neurosci. Abstr. 26 (2000) 1490.

45. O’Donnell, P. and Goto, Y. Nucleus accumbens neuron bistable membrane potential correlates with hippocampal local field potential. Soc. Neurosci. Abstr. 26 (2000) 1490.

44. Peters, Y.M. and O’Donnell, P. Membrane potential state transitions in prefrontal cortical pyramidal neurons correlate with VTA field potentials in vivo. Soc. Neurosci. Abstr. 26 (2000) 1711.

43. Wang, J. and O’Donnell, P. D1 and NMDA receptors synergistically increase excitability of rat prefrontal cortical pyramidal neurons. Soc. Neurosci. Abstr. 26 (2000) 1935.

42. Greene, J.M. and O’Donnell, P. Serotonergic regulation of nucleus accumbens cell firing in vivo. Soc. Neurosci. Abstr. 26 (2000) 1978.

41. O’Donnell, P., Lewis, B.L., Wang, J. and Peters, Y.M. Dopamine-glutamate interactions in the prefrontal cortex: changes in animal models of schizophrenia. Journal of Alzheimer’s Disease 2 (2000) 161.

40. Peters, Y.M., Lewis, B.L. and O’Donnell, P. Synchronous activity in the ventral tegmental area and prefrontal cortex. Annals of the New York Academy of Sciences 909 (2000) 267-269.

39. Shoblock, J. and O’Donnell, P. Histamine in the nucleus accumbens. Annals of the New York Academy of Sciences 909 (2000) 270-272.

38. Lipska, B.K., Bertolino, A., O’Donnell, P. and Weinberger, D.R. Neonatal damage of the rat hippocampus results in a constellation of schizophrenia-like phenomena. Biological Psychiatry 47 (2000) 119S.

37. O’Donnell, P., Lewis, B.L., Lerman, D., Weinberger, D.R. and Lipska, B.K. Effects of neonatal hippocampal lesions on prefrontal cortical pyramidal cell responses to VTA stimulation. Soc. Neurosci. Abstr. 25 (1999) 1659.

36. Lewis, B.L and O’Donnell, P. Stimulation of VTA induces membrane potential state transitions in prefrontal cortical neurons recorded in vivo. Soc. Neurosci. Abstr. 25 (1999) 1659.

35. Shoblock, J. and O’Donnell, P. Tuberomammilary modulation of nucleus accumbens neurons response to prefrontal cortical afferents. Soc. Neurosci. Abstr. 25 (1999) 1157.

34. Greene, J., Pabello, N. and O’Donnell, P. Monoamine regulation of nucleus accumbens cell firing in vivo. Soc. Neurosci. Abstr. 25 (1999) 1654.

33. Lewis, B.L., Peters, Y.M. and O’Donnell, P. Role of the VTA projection to the prefrontal cortex on activity states of pyramidal neurons. Gordon Research Conference in Catecholamines. Queen’s College, Oxford, UK (1999).

32. Grace, A.A., Onn, S.-P., O’Donnell, P. and Moore, H. Modulation of neuronal interactions within the nucleus accumbens by limbic cortical afferents: Alteration by repeated administration of amphetamine. American College of Neuropsychopharmacology Abstracts (1998).

31. Lewis, B. and O’Donnell, P. Effects of VTA stimulation on prefrontal cortex neurons recorded in vivo. Soc. Neurosci. Abstr. 24 (1998) 656.

30. O’Donnell, P. Dopamine and ensemble coding in the striatum and nucleus accumbens. International Basal Ganglia Society Meeting, Brewster, MA (1998).

29. O’Donnell, P. and Lewis, B. Dopaminergic control of prefrontal cortical activity: effect of VTA stimulation on bistable membrane potential of prefrontal cortical pyramidal neurons. Dopamine 98, Strasbourg, France (1998).

28. Carr, D.B., O’Donnell, P., Card, J.P. and Sesack, S.R. Dopamine terminals in the rat prefrontal cortex synapse on pyramidal cells that project to the nucleus accumbens. Dopamine 98, Strasbourg, France (1998).

27. O’Donnell, P. and Grace, A.A. PCP decreases the hippocampal-driven gating of accumbens neurons. Soc. Neurosci. Abstr. 23 (1997) 1282.

26. Carr, D.B., O’Donnell, P., Card, J.P., and Sesack, S.R. Dopamine terminals in the rat prefrontal cortex synapse on pyramidal cells that project to the nucleus accumbens. Soc. Neurosci. Abstr. 23 (1997) 1212.

25. O’Donnell, P. and Grace, A.A. Nitric oxide increases gap junction permeability between striatal neurons. Soc. Neurosci. Abstr. 22 (1996) 1201.

24. Grace, A.A. and O’Donnell, P. The modulation of corticoaccumbens transmission by hippocampal afferents and dopamine: a model for the pathophysiology of schizophrenia. VIII International Catecholamine Symposium (1996) 133.

23. O’Donnell, P. and Grace, A.A. Dopaminergic control of the bistable membrane potential of nucleus accumbens neurons: evidence from in vivo intracellular recordings. VIII International Catecholamine Symposium (1996) 172.

22. O’Donnell, P. and Grace, A.A. Hippocampal gating of cortical throughput in the nucleus accumbens: modulation by dopamine. Biological Psychiatry 39 (1996) 632.

21. Grace, A.A., O’Donnell, P., Lavín, A., and Card, J.P. A role for the hippocampus in context dependency: gating of prefrontal cortical information transfer in the nucleus accumbens. Consciousness Research Abstracts. Toward a Science of Consciousness “Tucson II” (1996) 80-81.

20. O’Donnell, P., Lavín, A., Grace, A.A., and Card, J.P. Segregated ventral pallidum-thalamic projections from the core and shell regions of the rat nucleus accumbens: transynaptic retrograde labeling using pseudorabies virus. Soc. Neurosci. Abstr. 21 (1995) 1188.

19. Grace, A.A. and O’Donnell, P. Dopamine inhibition of nucleus accumbens cell activity occurs via two independent mechanisms: evidence from in vivo and in vitro intracellular recordings. Soc. Neurosci. Abstr. 21 (1995) 1659.

18. O’Donnell, P. and Grace, A.A. Presynaptic interactions between dopaminergic and glutamatergic afferents in the nucleus accumbens: an in vitro electrophysiological study. Neuropharmacology III. Presynaptic Mechanisms of Neurotransmission (1995) 26.

17. O’Donnell, P. and Grace, A.A. Hippocampal afferents gate cortico-accumbens throughput: an in vivo intracellular study. Schizophrenia Research 15 (1995) 31.

16. O’Donnell, P. and Grace, A.A. Hippocampal gating of prefrontal cortical input onto nucleus accumbens neurons recorded intracellularly in vivo. Soc. Neurosci. Abstr. 20 (1994) 566.

15. O’Donnell, P. and Grace, A.A. Effects of chronic clozapine and haloperidol on electrotonic transmission in the nucleus accumbens and dorsal striatum. Dopamine '94, Quebec, Canada (1994).

14. Grace, A.A. and O’Donnell, P. Prefrontal cortical input to nucleus accumbens neurons is differentially modulated by dopaminergic and hippocampal afferents. Dopamine '94, Quebec, Canada (1994).

13. O’Donnell, P. and Grace, A.A. Endogenous dopamine tonically suppresses cortical-evoked EPSP in accumbens slices. Soc. Neurosci. Abstr. 19 (1993) 128.

12. O’Donnell, P. and Grace, A.A. Dopaminergic modulation of dye coupling between nucleus accumbens neurons: evidence for D1-D2 interaction. Schizophrenia Research 9 (1993) 246.

11. Grace, A.A. and O’Donnell, P. Clozapine exerts unique modulatory effects on accumbens cell interactions. American College of Neuropsychopharmacology Abstracts (1992) 76.

10. O’Donnell, P. and Grace, A.A. Electrophysiological properties of accumbens core and shell neurons. Soc. Neurosci. Abstr. 18 (1992) 697.

9. Grace, A.A., Onn, S.-P. and O’Donnell, P. Dye coupling between neurons in striatum and core and shell regions of the nucleus accumbens: differential modulation by D1 and D2 agonists. Dopamine '92: From Neurobiology to Neuropathology (1992) 111.

8. O’Donnell, P. and Grace, A.A. Dye coupling is differentially affected by apomorphine in accumbens core and shell neurons. Soc. Neurosci. Abstr. 17 (1991) 456.

7. O’Donnell, P. and Grace, A.A. Physiology and incidence of dye coupling in nucleus accumbens neurons. Third IBRO World Congress of Neuroscience Abstracts (1991) 146.

6. O’Donnell, P. and Pazo, J.H. Caracterización de dos poblaciones neuronales en el núcleo caudado. Medicina (Buenos Aires) 49 (1989) 418.

5. O’Donnell, P. and Pazo, J.H. Posible sustrato neuroanatómico de la acción moduladora de un núcleo caudado sobre el opuesto. Acta Physiologica et Pharmacologica Latinoamericana 38 (1988) 493.

4. Pazo, J.H., O’Donnell, P. and Murer, M.G. Modificaciones bilaterales en la actividad neuronal de la sustancia negra por lesiones unilaterales selectivas del estriado. Acta Physiologica et Pharmacologica Latinoamericana 38 (1988) 535-536.

3. O’Donnell, P., Murer, M.G., Gonzalez, M. and Pazo, J.H. Modulatory effect of central and peripheral inputs to the caudate nucleus. Neuroscience 22 suppl. (1987) S638.

2. O’Donnell, P. and Pazo, J.H. Efecto de la estimulación de un caudado sobre la actividad neuronal del núcleo contralateral. Medicina (Buenos Aires) 45 (1985) 328-329.

1. Pazo, J.H., Medina, J.H., O’Donnell, P. and Dvorkin, M.A. Papel de la corteza sensitivomotriz en el comportamiento inducido por L-DOPA. Acta Physiologica Latinoamericana 36 (1981) 76.